| Record Type: |
Electronic resources
: monographic
|
| Author: |
KyprianouNatasha, |
| Place of Publication: |
Singapore |
| Published: |
World Scientific; |
| Year of Publication: |
2012 |
| Description: |
1 online resource (230 p.) |
| Series: |
Molecular Medicine and Medicinal Chemistry |
| Subject: |
Prostate - Cancer - |
| Subject: |
Apoptosis - |
| Subject: |
Electronic books - |
| Online resource: |
http://www.worldscientific.com/worldscibooks/10.1142/P667#t=toc |
| Notes: |
9.1 Aspirin and Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) |
| Summary: |
This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis |
| ISBN: |
9781848164505electronic bk. |
| ISBN: |
1848164505electronic bk. |
| Content Note: |
Preface; Contents; Chapter 1 Introduction: Prostate Cancer; Chapter 2 The Prostate Gland Dyclmics; Chapter 3 Apoptosis Pathways Signaling Execution of Cancer Cells; 3.1 Cell Choices of Life and Death; 3.1.1 "Classic" apoptosis; 3.1.2 Anoikis; 3.2 Caspases: The Apoptosis Executioners in a Therapeutic Setting; 3.3 The Mitochondrion: A Convenient Cell-Killing Platform; 3.4 Cell Surface Death Receptors and the FAS Ligand; 3.5 Meet the BCL-2 Family: Governors of Cell Survival and Death; 3.6 The Transcriptional Controllers; 3.7 The p53 Tumor Suppressor |