| Record Type: |
Electronic resources
: monographic
|
| Author: |
DeyDipak, |
| Secondary Intellectual Responsibility: |
GhoshSamiran, |
| Secondary Intellectual Responsibility: |
MallickBani K., 1965- |
| Place of Publication: |
Boca Raton |
| Published: |
CRC Press; |
| Year of Publication: |
c2011 |
| Description: |
1 online resource (xxv, 440 p.)ill : |
| Series: |
Chapman & Hall/CRC biostatistics series |
| Subject: |
Bayes Theorem - |
| Subject: |
Computational Biology - |
| Subject: |
Models, Biological - |
| Subject: |
Bioinformatics - Statistical methods - |
| Subject: |
Bayesian statistical decision theory - |
| Online resource: |
http://www.crcnetbase.com/isbn/978-1-4200-7017-0 |
| Notes: |
"A Chapman & Hall book." |
| Summary: |
"Bayesian Modeling in Bioinformatics" discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and classification problems in two main high-throughput platforms: microarray gene expression and phylogenic analysis. The book explores Bayesian techniques and models for detecting differentially expressed genes, classifying differential gene expression, and identifying biomarkers. It develops novel Bayesian nonparametric approaches for bioinformatics problems, measurement error and survival models for cDNA microarrays, a Bayesian hidden Markov modeling approach for CGH array data, Bayesian approaches for phylogenic analysis, sparsity priors for protein-protein interaction predictions, and Bayesian networks for gene expression data. The text also describes applications of mode-oriented stochastic search algorithms, in vitro to in vivo factor profiling, proportional hazards regression using Bayesian kernel machines, and QTL mapping |
| ISBN: |
9781420070187electronic bk. |
| ISBN: |
1420070185electronic bk. |
| Content Note: |
List of Tables -- List of Figures -- Preface -- Symbol Description -- Chapter 1: Estimation and Testing in Time-Course Microarray Experiments -- Chapter 2: Classification for Differential Gene Expression Using Bayesian Hierarchical Models -- Chapter 3: Applications of the Mode Oriented Stochastic Search (MOSS) Algorithm for Discrete Multi-Way Data to Genomewide Studies -- Chapter 4: Nonparametric Bayesian Bioinformatics -- Chapter 5: Measurement Error and Survival Model for cDNA Microarrays -- Chapter 6: Bayesian Robust Inference for Differential Gene Expression |