| 紀錄類型: |
書目-電子資源
: 單行本
|
| 副題名: |
applications to drug discovery |
| 其他作者: |
LoDonald C., |
| 其他作者: |
HughesRobert E., |
| 出版地: |
Boca Raton |
| 出版者: |
CRC Press/Taylor & Francis Group; |
| 出版年: |
2010 |
| 面頁冊數: |
1 online resourceill. (some col.) : |
| 集叢名: |
Frontiers in neuroscience |
| 標題: |
Huntington's chorea - Pathophysiology - |
| 標題: |
Huntington's chorea - Molecular aspects - |
| 標題: |
Neuropharmacology - |
| 標題: |
Huntington Disease - physiopathology - |
| 標題: |
Drug Discovery - methods - |
| 標題: |
Huntington Disease - drug therapy - |
| 標題: |
Electronic books - |
| 電子資源: |
http://www.crcnetbase.com/isbn/978-0-8493-9000-5 |
| 附註: |
Description based on print version record |
| 摘要註: |
"Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening; highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders; examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families."--Publisher's description |
| ISBN: |
9781420008258e-book : PDF |
| ISBN: |
1420008250e-book : PDF |
| ISBN: |
hardcover : alk. paper |
| ISBN: |
hardcover : alk. paper |