| 紀錄類型: |
書目-電子資源
: 單行本
|
| 副題名: |
stem cells and beyond |
| 其他作者: |
EngelFelix B., |
| 出版地: |
Singapore |
| 出版者: |
World Scientific Pub. Co; |
| 出版年: |
2012 |
| 面頁冊數: |
1 online resource (xx, 372 p. :)col. ill. : |
| 標題: |
Stem cells - Research - |
| 標題: |
Heart - Diseases - |
| 標題: |
Electronic books - |
| 電子資源: |
http://www.worldscientific.com/worldscibooks/10.1142/7696#t=toc |
| 附註: |
Description based on print version record |
| 摘要註: |
Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury. This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials |
| ISBN: |
9789814299817electronic bk. |
| ISBN: |
9814299812electronic bk. |
| 內容註: |
I. Introduction to cardiac disease / Erin Bohula and Richard T. Lee II. Growth and differentiation of the developing heart / Bram van Wijk ... [et al.] III. Does heart regeneration occur? A. Cardiac regeneration in the newt / Thilo Borchardt and Thomas Braun. B. Zebrafish heart regeneration / Robert J. Major and Kenneth D. Poss. C. Regenerative potential of the mammalian heart / May Liang-Lam and William C. Claycomb IV. Repopulation of the heart with new cardiomyocytes. A. Induction of cardiomyocyte proliferation / Machteld J. van Amerongen and Felix B. Engel. B. Multipotent progenitor cells in regenerative cardiovascular medicine / Jason T. Lam, Alessandra Moretti and Karl-Ludwig Laugwitz. C. Circulating progenitor cells / Masamichi Koyanagi and Stefanie Dimmeler. D. Pluripotent stem cells for cardiac repair / Kara White Moyes, Scott D. Lundy and Michael A. Laflamme V. What is the paracrine effect of stem cells? A. Stem cell therapy for heart repair: the paracrine paradigm / Massimiliano Gnecchi, Maria Mirotsou and Victor J. Dzau. B. Delivery systems to the heart / Kathryn M. Rafferty and Michael E. Davis VI. How to create an artificial heart ex vivo? A. The mechanical heart / JoAnn Lindenfeld and Patricia A. Kelly. B. Engineered heart tissue / Thomas Eschenhagen and Wolfram-Hubertus Zimmermann VII. The complexity of organ regeneration / Tatyana Novoyatleva and Felix B. Engel VIII. Cell therapy trials in patients with coronary heart disease / Kai C. Wollert |